G-1438

2025-10-19 17:46

Written by ARCIMS 26 ARCIMS 26 in Sunday 2025-10-19 17:46

The Association Between Mineral Intake and Sleep Quality in Patients Undergoing Angiography at Afshar Hospital, Yazd: A Cross-Sectional Study

 Amirreza Ghasemi 1 ℗, Kimia Rostampour 1, Amin Salehi Abargouei 2 ©   

1 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 

2 Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Email: a.ghasemi.diet@gmail.com
 

 


 
Abstract

Introduction: Sleep disturbances, including poor sleep quality and deprivation, are increasingly prevalent in today’s society. Given sleep’s vital role in cardiovascular (CV) health and the bidirectional relationship between sleep disorders and cardiovascular disease (CVD), this connection warrants deeper exploration. Nutrition, particularly mineral intake, is a significant factor in sleep regulation. This study investigates the association between mineral intake and sleep quality among patients with cardiovascular disease. Methods and Materials: This cross-sectional study involved 653 patients aged 35–75 who were referred for angiography between July 2020 and November 2021 at Afshar Hospital in Yazd, Iran. Dietary intake and sleep quality were assessed using the FFQ-182 and Pittsburgh Sleep Quality Index (PSQI), respectively. The PSQI evaluates seven components of sleep and generates a total score indicating overall sleep quality. The fully adjusted model accounted for variables such as age, sex, energy intake, socioeconomic status, education, occupation, marital status, mental health, physical activity, BMI, diabetes, smoking, substance use, and caffeine intake. Binary logistic regression was used as the primary method of analysis to examine the associations between mineral intake and sleep quality outcomes. Results: In crude models, higher intake of magnesium, phosphorus, calcium, sodium, and potassium was significantly linked to better overall sleep quality. The corresponding odds ratios and confidence intervals were: calcium (OR = 0.46; 95% CI: 0.31–0.69; P Trend 0.001), sodium (OR = 0.54; 95% CI: 0.36–0.81; P Trend = 0.03), potassium (OR = 0.58; 95% CI: 0.39–0.87; P Trend = 0.001), magnesium (OR = 0.60; 95% CI: 0.40–0.90; P Trend = 0.002), and phosphorus (OR = 0.42; 95% CI: 0.26–0.67; P Trend 0.001). However, after adjusting for confounding variables, none of these associations remained statistically significant. Among the analyzed minerals, phosphorus was the only one to show a notable association with sleep latency in the final model. Individuals with higher phosphorus intake had a 67% lower likelihood of experiencing delayed sleep onset compared to those with lower intake (OR = 0.33; 95% CI: 0.12–0.94; P Trend = 0.65). In the fully adjusted models, no significant relationships were observed between the remaining minerals and specific sleep quality components. Conclusion and Discussion: Higher phosphorus intake is linked to reduced sleep latency in patients undergoing coronary angiography, suggesting a potential role in improving sleep onset. Adequate phosphorus levels may support more efficient neuronal communication, potentially facilitating the initiation of sleep. No significant associations were found between other mineral intakes and overall sleep quality or its specific components after controlling for confounders. Consequently, further research employing rigorous designs, such as cohort studies and randomized controlled trials, is necessary to confirm these findings and to explore the neurophysiological mechanisms underlying the observed association.


Keywords: Minerals; Sleep quality; Cardiovascular disease; Sleep latency; Phosphorus intake

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