ARCIMS 26
in
Sunday 2025-10-19 17:42
Comparative Analysis of P53 Marker Expression in Dentigerous Cysts and Calcifying Odontogenic Cysts: A Cross-sectional Immunohistochemical Study
Samira Mostafazadeh 1 ©, Nesa Rasooli 2 ℗, Babak Ebrahimi 2
Abstract
Introduction: Both calcifying odontogenic cysts (COCs) and dentigerous cysts (DCs) are classified as developmental jaw lesions, but COCs tend to display more aggressive behavior and demonstrate an increased likelihood of being neoplastic. The p53 protein that is frequently referred to as a tumor suppressor is instrumental in cell cycle control and malignant transformation prevention. The goal here was to assess and cross check the expression of p53 marker in COCs and DCs using immunohistochemistry techniques. Methods and Materials: This descriptive cross-sectional study focused on the archived COCs and DCs cases collected from 2000 to 2022 in Urmia's pathology center. The selected paraffin embedded samples underwent histopathological diagnosis and subsequently p53 immunohistochemistry staining. The percentage of positively staining epithelial cells was recorded and statistically compared between the groups. Results: In COC group the mean p53 expression was significantly higher, compared to DC group with the former displaying 59.55% ± 13.73 and the latter 33.45% ± 11.86 accompanied by a statistically significant difference p value of 0.001. This is provided to confirm greater activity of proliferative processes in COCs. Conclusion and Discussion: It appears that p53 expression is elevated in calcifying odontogenic cysts as there is heightened aggressive or neoplastic behavior when compared to dentigerous cysts. Furthermore, p53 expression could be considered a useful indicator for assessing the aggressiveness and neoplastic potential of odontogenic cysts.
Keywords: p53, dentigerous cyst, calcifying odontogenic cyst, immunohistochemistry, jaw lesions
