G-1711

2025-10-19 17:29

Written by ARCIMS 26 ARCIMS 26 in Sunday 2025-10-19 17:29

The Effects of Aerobic and Yoga Training on Serum Levels of F2-isoprostanes and Growth Differentiation Factor-15 in Obese Women with Type 2 Diabetes: A Randomized Controlled Trial

 Amirreza Khamineh Jahromi 1 ℗, Hamed Zamanpoor 2, Negar Norouzi 1, Amir Goli 1, Mohammad Nosrati-Oskouie 3 ©   

 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.

 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz, University of Medical Sciences, Tabriz, Iran

    Email: amirrezakhamineh1@gmail.com
 

 


 
Abstract

Introduction: This randomized controlled trial aimed to evaluate the effects of 12 weeks of aerobic and yoga training on oxidative stress and systemic inflammation in obese women with type 2 diabetes (T2D), using serum F2-isoprostanes (F2-IsoPs) and growth differentiation factor-15 (GDF-15) as biomarkers. Methods and Materials: 28 sedentary obese women with T2D (aged 46–60) were randomly assigned to aerobic (n = 10), yoga (n = 10), and control (no intervention, n = 8) groups and provided written informed consent (IR.UT.SPORT.REC.1403.101). Participants in the intervention arms completed supervised 60-minute sessions thrice weekly for 12 weeks. The aerobic group performed moderate-intensity cardiovascular exercises (progressing from 60% to 70% HRmax), while the yoga group followed a progressively intensified sequence of asanas, pranayama, and meditation. Serum F2-IsoPs and GDF-15 levels were measured pre- and post-intervention using ELISA. Statistical analyses included repeated measures ANOVA, ANCOVA (adjusted for baseline, age, and duration of diabetes), correlation, and responder analysis (≥10% biomarker reduction. Results: No significant time × group interaction or group effect was found for F2-IsoPs or GDF-15. GDF-15 changed significantly over time (p = 0.047), but between-group differences were non-significant (p = 0.781). Responder analysis showed ≥10% GDF-15 reduction in 30% of yoga, 40% of aerobic, and 12.5% of control participants. Baseline F2-IsoP levels strongly predicted post-intervention reduction (r = –0.706, p 0.001). Conclusion and Discussion: Twelve weeks of moderate-intensity aerobic or yoga training did not significantly alter serum F2-IsoP or GDF-15 levels. Longer duration, higher intensity, or combined lifestyle strategies may be required to produce meaningful reductions in oxidative stress and inflammation in obese women with T2D.


Keywords: Type 2 diabetes, obesity, F2-isoprostanes, GDF-15, yoga, aerobic exercise

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