G-2854

Recent advances of using nanostructure fluorescent materials for determination of drugs in biological samples

 Mohammad Mahdi Hatami ¹ ℗, Salar Mohammadi1 ², Farnoosh Miri ², Zahra Meshkani ², Esmaeil Mohammadian ³ ©, Mahmood Alizadeh Sani ⁴   

 
Abstract

Introduction: Drug measurement in biological samples is vital for therapeutic monitoring, pharmacokinetics, toxicology, bioavailability, clinical trials, and personalized medicine. Nanoparticles enhance drug analysis by improving sensitivity, specificity, speed, and multi-drug detection due to their large surface area and functional properties. Commonly used nanoparticles include gold and copper nanoclusters, various carbon and graphene quantum dots, lanthanide ions, core-shell upconversion particles, and metal-organic frameworks. These sensors, based on inner filter and antenna effects, offer efficient drug detection. This study reviews nanoparticle-based drug analysis methods, sensor mechanisms, detection limits, and the efficiency and selectivity of nanosensors. Search Strategy: A systematic literature search was performed using PubMed, Embase, Scopus, and Web of Science databases to identify relevant studies published between 2020 and 2024. The search strategy included combinations of

Keywords: Nanosensor, Nanostructure fluorescent material, Biological samples, Analysis of drugs, Method